Determination of the median effective dose (ED50) of bupivacaine and ropivacaine unilateral spinal anesthesia

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[Unilateral spinal anesthesia with low 0.5% hyperbaric bupivacaine dose.].

BACKGROUND AND OBJECTIVES Unilateral spinal anesthesia may be advantageous, especially for outpatient procedures. Low anesthetic doses, pencil point or cutting point needles, slow injection rate and the lateral position have been reported as helping unilateral spinal anesthesia technique. This longitudinal study aimed at investigating the depth of unilateral spinal anesthesia with 5 mg of 0.5% ...

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Intrathecal anesthesia: ropivacaine versus bupivacaine.

We compared intrathecal ropivacaine to bupivacaine in patients scheduled for transurethral resection of bladder or prostate. Doses of ropivacaine and bupivacaine were chosen according to a 3:2 ratio found to be equipotent in orthopedic surgery. One hundred patients were randomly assigned to blindly receive either 10 mg of isobaric bupivacaine (0.2%, n = 50) or 15 mg of isobaric ropivacaine (0.3...

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Effect of Concentration on Median Effective Dose (ED50) for Motor Block of Intrathecal Plain Bupivacaine in Elderly Patients

BACKGROUND The aim of the study was to determine the median effective dose (ED50) for motor block of various concentrations of intrathecally administered plain bupivacaine. MATERIAL AND METHODS Between 2011 and 2013, 64 patients aged ≥70 years, undergoing transurethral, or lower limb surgery with combined spinal and epidural anesthesia in a single hospital were enrolled. The patients were ran...

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A question about ropivacaine for unilateral spinal anesthesia: hypobaric solution.

1. Nuri Deniz M, Erakgün A, Sertöz N, et al. The effect of head rotation on intraocular pressure in prone position: a randomized trial. Rev Bras Anestesiol. 2013;63:209--12. 2. Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 1996;17:1--12. 3. Walick KS, Kragh JE Jr, Ward JA, et al. Changes in intra...

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Optimal dose of hyperbaric bupivacaine 0.5% for unilateral spinal anesthesia during diagnostic knee arthroscopy

OBJECTIVE To determine the dose of hyperbaric bupivacaine 0.5% required for unilateral spinal anesthesia during diagnostic knee arthroscopy. PATIENTS AND METHODS This prospective, randomized, clinical study was performed in 80 patients who were assigned to four groups to receive different doses of intrathecal hyperbaric bupivacaine (5 mg, 7.5 mg, 10 mg and 12.5 mg in Groups 1, 2, 3, and 4 res...

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ژورنال

عنوان ژورنال: Der Anaesthesist

سال: 2017

ISSN: 0003-2417,1432-055X

DOI: 10.1007/s00101-017-0370-9